Current Issue : January - March Volume : 2017 Issue Number : 1 Articles : 5 Articles
The self emulsified drug delivery system (SEDDS) is characteristic property of water-in-oil emulsion formulation which gets emulsified by little motility in GIT. The mixture of surfactant and co-surfactant forms stable emulsion which have minimal free energy as it forms with minimal energy of emulsification. The excipients were selected with drug solubility and the flow ability of emulsion with the basic criteria. These were selected by ternary phase diagram plot with criteria of easy dispersibility, stability and transparency after addition in water (outer phase). Particle size analysis showed sizes of the resultant microspheres that were approximately 100 µm or less. SEDDS have high loading efficiencies due to its excipients and have efficient drug release profile. The maximum drug gets released in early 10 min. which cause efficient formulation of low bio-available drug....
The aim of the present study was to formulate, evaluate and optimize fast dissolving tablets of glimepiride. Glimepiride is one of the third generation sulfonylurea used for treatment of type 2 diabetes. Poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible clinical response or therapeutic failure in some cases due to sub therapeutic plasma drug levels. Consequently, the rationale of this study was to improve the solubility, dissolution rate and biological performance of the drug. Solid dispersion of glimepiride with polyethylene glycol 6000 was prepared by fusion method. Further solid dispersions were formulated as fast dissolving tablets by direct compression technique using superdisintegrants like sodium starch glycolate (SSG) and croscarmellose sodium (CCS) in different concentrations. SDs was evaluated for FTIR, DSC, XRD and SEM, in-vitro dissolution profiles. Among different formulations of SDs, SD prepared by fusion method containing drug to polyethylene glycol 6000 in the ratio of 1:2 by fusion method gives best dissolution profile and among tablet formulations, containing 30% cross carmellose sodium (CCS) gives faster disintegration and dissolution profiles compared with other formulations. Results showed that polyethylene glycol 6000 is a promising carrier for enhancing the solubility of glimepiride. Prepared tablets were evaluated for angle of repose, weight variation, hardness, %friability, wetting time, drug content, disintegration and in-vitro dissolution studies. The results of stability studies revealed no change in physical appearance, drug content and in-vitro dissolution profile, thus indicating that formulations was stable. FTIR, DSC, XRD and SEM studies revealed that there was no significant interaction between drug and polymer in the formulations. Among all the formulations, Formulation GP6 prepared with croscarmellose sodium (CCS 30%) was found to be optimized as compared with other formulations....
Saxagliptin HCl is a potent, selective, reversible dipeptidyl peptidase 4 (DPP4) inhibitor. Glipizide is second generation\nsulphonylurea drug. The combination of therapy of two drugs with different mechanism of action minimizes unwanted side\neffects and lowers the dose of antihyperglycemic agent. A multilayer tablet with one layer of immediate release and another\nlayer of sustained release will have wide spread acceptability. Co-administration of two drugs was achieved by formulating\nsaxagliptin HCl and glipizide into two separated layers of bilayer tablet. A simultaneous analytical method was developed for\nboth the drugs using UV Vis spectrophotometric technique and validated as per ICH (Q2, R1) guidelines. An immediate release\nlayer of saxagliptin HCl was prepared and then another layer of glipizide sustained release was compressed on it. P4 of\nimmediate release formulation and F6 of sustained release formulation give release as per IP specification. It was concluded that\nthe bilayer tablets prepared provide an effective combination therapy for T2DM....
Aim of present study was to formulate, optimize and evaluate mouth dissolving tablet of palonosetron hydrochloride.\nTablet was formulated by direct compression method by using different super disintegrating agents like crospovidone,\ncroscarmellose sodium and sodium starch glycollate. For optimization of final formulation 32 factorial design was applied. The\nconcentration of microcrystalline cellulose and crospovidone were selected as an independent variable and disintegration time,\nwetting time and in-vitro drug release as dependent variable. Formulations were evaluated for parameters like hardness,\ndisintegration time, in-vitro drug release study, wetting time, drug content and drug excipients compatibility study. Study\ndemonstrates that the release profile depends on the concentration of crospovidone. The optimized formula obtained from\ndifferent factorial batches of experimental design matches with the predicted value from design expert software. The optimized\nbatch was evaluated for the parameters like hardness, disintegration time, in-vitro drug release study, wetting time and drug\ncontent. The final formulation was stable after 3 months stability study as per ICH guideline conditions. The studies indicate that\nthe formulation was having less disintegration time as well as fast in-vitro drug release. Crospovidone is the key ingredient\nwhich significantly affects disintegration time as well as fast drug release effect. Fast dissolving formulation of palonosetrone\nHCl can be successfully formulated and used for patients who refuse to swallow conventional tablets such as pediatric, geriatric\nand psychiatric patients....
Amoxicillin trihydrate (a-amino-hydroxybenzyl-penicillin) is a semi synthetic, orally absorbed, broad-spectrum antibiotic. It is a drug of choice in the treatment of infections including chest (bronchitis/pneumonia), ears (otitis media), gonorrhea and urinary tract infections. The present work was carried out to formulate, optimize and evaluate a reconstitutable suspension of amoxicillin trihydrate for oral administration by using various techniques like physical mixing, solvent evaporation, co-grinding and lyophilization method with different suspending agents like xanthan gum, sodium alginate and compound tragacanth powder. The reconstitutable suspensions were evaluated for flow properties, particle size, pH, viscosity, sedimentation volume, redispersibility and drug release by in-vitro dissolution studies. The drug excipients Interactions and crystal morphology of optimized reconstitutable suspension were evaluated by FTIR and DSC analysis. The results indicated that the release of the amoxicillin trihydrate was rapid from all formulations than the pure drug. The drug release from the suspensions followed first order kinetics. Among all formulations the formulation prepared by lyophilization method released the drug rapidly than the pure drug and other formulations....
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